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New Lab Member - Mar Corgos

We are happy to have welcomed Mar Corgos to our team since last December!
Mar recently defended her Bachelor thesis at the IQS Barcelona and completed her internship on Tendon/Ligament scaffold generation at Fachhochschule Technikum Wien.
She is working in our team as a Master Student under the mentoring of Marie Brinkmann on targeting osteoclastogenesis in rheumatoid arthritis: characterizing epigenetic drug mechanisms.

Welcome Mar, we wish you a smooth on-boarding and successful time with us!

Jan 10, 2025

Launch of a new IHI project - AutoPix

AutoPix-project has officially started and we as the Bonelli Lab are proud to be part of it!
This new Innovative Health Initiative (IHI) co-funded by the European Union and the pharma industry aims to revolutionize imaging biomarkers for patients with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis.
Our contribution, together with the team of Costantino Pitzalis at Queen Mary University of London, will link imaging biomarkers to liquid & cellular biomarkers from patients’ biopsies.

Further details of AutoPix are found here: https://lnkd.in/dURfhvdA

Jan 03, 2025

HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

Philipp Penninger, Helena Brezovec, Irina Tsymala, Magdalena Teufl, Trinh Phan-Canh, Tamires Bitencourt, Marie Brinkmann, Walter Glaser, Wilfried Ellmeier, Michael Bonelli, Karl Kuchler

Dec 27, 2024

View on PubMed

Lilly Innovation Award received by Marie

We are proud to share that our PhD student, Marie Brinkmann, has been awarded the Eli Lilly and Company Award at this year’s Congress of the Austrian Society of Rheumatology – Österreichische Gesellschaft für Rheumatologie & Rehabilitation (ÖGR). 🎉
This competitive award supports outstanding pilot projects in rheumatology with up to 12 months of funding, and it will help advance Marie’s important research in the field.
Congratulations to Marie on this well-deserved recognition!

Dec 13, 2024

Spotlight on rheumatic diseases & research in ORF

Delve into future personalized medical approaches in rheumatology with Daniel Aletaha and Michael Bonelli, featured in an ORF interview.

We express our gratitude to ORF for their support in raising awareness about rheumatic diseases and research.

The full in can be watched here in German: https://tv.orf.at/treffpunkt2142.html (jump to 33:16 for our part).

Dec 06, 2024

Ludwig Boltzmann Institue for Network Medicine

🎉Exciting times for science! The Ludwig Boltzmann Institute for Network Medicine (LBI NetMed) officially launched under the leadership of Jörg Menche.  This innovative research initiative, supported by the Ludwig Boltzmann Gesellschaft aims to tackle complex challenges at the intersection of medicine and network science.
Michael had the pleasure of attending the vibrant welcome party, complete with guided tours of the institute’s cutting-edge facilities and live music that set the tone for a promising future. 
Congratulations to Jörg and the entire team at LBI NetMed! Wishing you groundbreaking discoveries and success in your mission to redefine network medicine. 🚀
Check out more about LBI NetMed here: https://netmed.lbg.ac.at/

Nov 29, 2024

Funded Post-doctoral Researcher position in the field of Autoimmunity

We are looking for a highly motivated, curiosity-driven and independent Postdoctoral Researcher to join our research team to explore molecular mechanisms leading to the development of immune-related non-communicable diseases (IR-NCD), with a focus on rheumatic diseases, in particular Rheumatoid Arthritis (RA).

Further information here: https://innere-med-3.meduniwien.ac.at/en/unsere-abteilungen/rheumatologie/research/group-of-michael-bonelli/jobangebote/phd-student-position-fully-funded-start-march-2024-3/

Nov 26, 2024

Our Team at the Squeeze General Assembly, Bucharest

We were thrilled to reconnect with our partners Costantino Pitzalis and Felice Rivellese from Queen Mary University of London, at the latest SQUEEZE project general assembly in Bucharest! 🤝 One of the focus was on the BioTest trial and refining our strategies to advance precision medicine for RA patients. 🧬 Alongside our experts Peter Mandl MD, PhD, Leonhard Heinz, Lisabeth Emilius, and our scientific project manager François Bonnay, PhD, we renewed our shared commitment to establish groundbreaking biomarkers for treatment success using synovial biopsies. 🔬
A heartfelt thank you to the SQUEEZE and Carol Davila University of Medicine and Pharmacy teams for organizing such a productive and energizing meeting! 🌟

Nov 14, 2024

Our PhD student Mirjam Dellinger started a collaboration in London!

We are thrilled to announce that our talented PhD student Mirjam Dellinger has successfully started a six-months collaboration with the team of Costantino Pitzalis and Felice Rivellese at Queen Mary University of London within the frame of the ambitious Horizon-Europe SQUEEZE project!

Among other things, Mirjam will learn to process and analyze synovial biopsy samples from Rheumatoid Arthritis patients, a key expertise from Queen Mary University of London, and an important task within SQUEEZE that will ultimately advance Precision Medicine for RA patients. Our thanks also go to Costantino and Felice for welcoming Mirjam in their team, and to SQUEEZE and the Marietta Blau-Stipendium (Austria’s Agency for Education and Internationalization) for the financial support of this collaboration.

Sep 25, 2024

CCR6 controls autoimmune but not innate immunity-driven experimental arthritis. J Cell Mol Med.

Michael Bonelli, Antonia Puchner, Lisa Göschl, Silvia Hayer, Birgit Niederreiter, Guenter Steiner, Katharina Tillmann, Roberto Plasenzotti, Bruno Podesser, Philippe Georgel, Josef Smolen, Clemens Scheinecker, Stephan Blüml. 

Journal of Cellular and Molecular Medicine

Sep 01, 2024

View on PubMed

Funded Master thesis in the field of autoimmunity (call closed)

📣Our lab is recruiting again, help us spread the word! 📣 We are offering a (paid) Master student position to study with us the role of epigenetic modifications in Arthritis. Check our job ad on the link or the attached pictures below 👇

https://innere-med-3.meduniwien.ac.at/unsere-abteilungen/rheumatologie/wissenschaft-forschung/arbeitsgruppe-michael-bonelli/jobangebote/phd-student-position-fully-funded-start-march-2024/

Universitätsklinik für Innere Medizin III

Aug 28, 2024

Our Team celebrates summer in Vienna!

Our team is embracing the summer in Vienna and proudly accomplished a “Rätselrallye” during our annual summer retreat last week! This activity consisted in a treasure hunt and riddle-solving exercise testing our dedicated researchers on their knowledge of our beloved city. Well-deserved dinner & drinks followed to reward our team. Summery greetings from Vienna!

Medical University of Vienna

Aug 23, 2024

Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story. Ann Rheum Dis.

Michael Bonelli, Andreas Kerschbaumer, Kastriot Kastrati, Kamran Ghoreschi, Massimo Gadina, Leonhard X Heinz, Josef S Smolen, Daniel Aletaha, John O’Shea, Arian Laurence.

Annals of the Rheumatic Diseases

Nov 03, 2023

View on PubMed

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis.

Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Müller, Teresa Preglej, Leonhard X Heinz, Elisabeth Simader, Lisa GÃschl, Stephan E Puchner, Sebastian Weiss, Lisa E Shaw,
Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S Smolen, Guenter Steiner, Daniel Aletaha, Hans P Kiener, Myles J Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli, 







Annals of the Rheumatic Diseases

Jun 21, 2023

View on PubMed

Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach. Front Immunol.

Teresa Preglej, Marie Brinkmann, Günter Steiner, Daniel Aletaha, Lisa Göschl, Michael Bonelli

Frontiers in Immunology

Mar 23, 2023

View on PubMed

Neuropsychiatric Systemic Lupus Erythematosus: A Remaining Challenge. Curr Pharm Des.

Daniel Mrak, Michael Bonelli* and Helga Radner.

Bentham Science

May 27, 2022

View on PubMed

Tocilizumab in patients with new onset polymyalgia rheumatica (PMR-SPARE): a phase 2/3 randomised controlled trial. Ann Rheum Dis.

Michael Bonelli, Helga Radner, Andreas Kerschbaumer, Daniel Mrak, Martina Durechova, Jutta Stieger, Rusmir Husic, Peter Mandl, Josef S Smolen, Christian Dejaco, Daniel Aletaha.

Annals of the Rheumatic Diseases

Feb 24, 2022

View on PubMed

Treg cells in health and autoimmune diseases: New insights from single cell analysis. J Autoimmun.

Clemens Scheinecker, Lisa Göschl, Michael Bonelli.

Journal of Autoimmunity

Jun 20, 2020

View on PubMed

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun.

Lisa Göschl, Teresa Preglej, Nicole Boucheron, Victoria Saferding, Lena Müller, Alexander Platzer, Kiyoshi Hirahara, Han-Yu Shih, Johan Backlund, Patrick Matthias, Birgit Niederreiter, Anastasiya Hladik, Maximilian Kugler, Guido A. Gualdoni, Clemens Scheinecker, Sylvia Knapp, Christian Seiser, Rikard Holmdahl, Katharina Tillmann, Roberto Plasenzotti, Bruno Podesser, Daniel Aletaha, Josef S. Smolen, Thomas Karonitsch, Günter Steiner, Wilfried Ellmeier, Michael Bonelli.

Journal of Autoimmunity

Mar 25, 2020

View on PubMed

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs. Exp Mol Med.

Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, Günter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener & Thomas Karonitsch

Experimental & Molecular Medicine

Jul 08, 2019

View on PubMed

HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

Philipp Penninger, Helena Brezovec, Irina Tsymala, Magdalena Teufl, Trinh Phan-Canh, Tamires Bitencourt, Marie Brinkmann, Walter Glaser, Wilfried Ellmeier, Michael Bonelli, Karl Kuchler

Dec 27, 2024

View on PubMed

CCR6 controls autoimmune but not innate immunity-driven experimental arthritis. J Cell Mol Med.

Michael Bonelli, Antonia Puchner, Lisa Göschl, Silvia Hayer, Birgit Niederreiter, Guenter Steiner, Katharina Tillmann, Roberto Plasenzotti, Bruno Podesser, Philippe Georgel, Josef Smolen, Clemens Scheinecker, Stephan Blüml. 

Journal of Cellular and Molecular Medicine

Sep 01, 2024

View on PubMed

Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story. Ann Rheum Dis.

Michael Bonelli, Andreas Kerschbaumer, Kastriot Kastrati, Kamran Ghoreschi, Massimo Gadina, Leonhard X Heinz, Josef S Smolen, Daniel Aletaha, John O’Shea, Arian Laurence.

Annals of the Rheumatic Diseases

Nov 03, 2023

View on PubMed

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis.

Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Müller, Teresa Preglej, Leonhard X Heinz, Elisabeth Simader, Lisa GÃschl, Stephan E Puchner, Sebastian Weiss, Lisa E Shaw,
Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S Smolen, Guenter Steiner, Daniel Aletaha, Hans P Kiener, Myles J Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli, 







Annals of the Rheumatic Diseases

Jun 21, 2023

View on PubMed

Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach. Front Immunol.

Teresa Preglej, Marie Brinkmann, Günter Steiner, Daniel Aletaha, Lisa Göschl, Michael Bonelli

Frontiers in Immunology

Mar 23, 2023

View on PubMed

Neuropsychiatric Systemic Lupus Erythematosus: A Remaining Challenge. Curr Pharm Des.

Daniel Mrak, Michael Bonelli* and Helga Radner.

Bentham Science

May 27, 2022

View on PubMed

Tocilizumab in patients with new onset polymyalgia rheumatica (PMR-SPARE): a phase 2/3 randomised controlled trial. Ann Rheum Dis.

Michael Bonelli, Helga Radner, Andreas Kerschbaumer, Daniel Mrak, Martina Durechova, Jutta Stieger, Rusmir Husic, Peter Mandl, Josef S Smolen, Christian Dejaco, Daniel Aletaha.

Annals of the Rheumatic Diseases

Feb 24, 2022

View on PubMed

Treg cells in health and autoimmune diseases: New insights from single cell analysis. J Autoimmun.

Clemens Scheinecker, Lisa Göschl, Michael Bonelli.

Journal of Autoimmunity

Jun 20, 2020

View on PubMed

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun.

Lisa Göschl, Teresa Preglej, Nicole Boucheron, Victoria Saferding, Lena Müller, Alexander Platzer, Kiyoshi Hirahara, Han-Yu Shih, Johan Backlund, Patrick Matthias, Birgit Niederreiter, Anastasiya Hladik, Maximilian Kugler, Guido A. Gualdoni, Clemens Scheinecker, Sylvia Knapp, Christian Seiser, Rikard Holmdahl, Katharina Tillmann, Roberto Plasenzotti, Bruno Podesser, Daniel Aletaha, Josef S. Smolen, Thomas Karonitsch, Günter Steiner, Wilfried Ellmeier, Michael Bonelli.

Journal of Autoimmunity

Mar 25, 2020

View on PubMed

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs. Exp Mol Med.

Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, Günter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener & Thomas Karonitsch

Experimental & Molecular Medicine

Jul 08, 2019

View on PubMed

Treg cells in autoimmunity: from identification to Treg-based therapies. Semin Immunopathol.

Lisa Göschl, Clemens Scheinecker, Michael Bonelli.

Springer Link

Apr 05, 2019

View on PubMed

How does abatacept really work in rheumatoid arthritis? Curr Opin Rheumatol.

Michael Bonelli, Clemens Scheinecker

Annals of the Rheumatic Diseases

May 01, 2018

View on PubMed

A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun.

Lisa Göschl, Teresa Preglej, Patricia Hamminger, Michael Bonelli, Liisa Andersen, Nicole Boucheron, Alexandra F. Gülich, Lena Müller, Victoria Saferding, Ilgiz A. Mufazalov, Kiyoshi Hirahara, Christian Seiser, Patrick Matthias, Thomas Penz, Michael Schuster, Christoph Bock, Ari Waisman, Günter Steiner, Wilfried Ellmeier

Journal of Autoimmunity

Jan 04, 2018

View on PubMed

Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford).

Michael Bonelli, Lisa Göschl, Stephan Blüml, Thomas Karonitsch, Kiyoshi Hirahara, Elisabeth Ferner, Carl-Walter Steiner, Günter Steiner, Josef S. Smolen, Clemens Scheinecker

Rheumatology (Oxford)

Apr 04, 2016

View on PubMed

CD4⁺CD25⁻Foxp3⁺ T cells: a marker for lupus nephritis? Arthritis Res Ther.

Michael Bonelli, Lisa Göschl, Stephan Blüml, Thomas Karonitsch, Carl-Walter Steiner, Günter Steiner, Josef S Smolen & Clemens Scheinecker

Arthritis Research & Therapy

Apr 28, 2014

View on PubMed

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol.

Michael Bonelli, Han-Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno & John J. O’Shea

Curr Top Microbiol Immunol

Jan 01, 2014

View on PubMed

Abatacept (CTLA-4Ig) treatment reduces the migratory capacity of Monocytes in patients with rheumatoid arthritis. Arthritis Rheum.

M Bonelli, E Ferner, L Göschl, S Blüml, A Hladik, T Karonitsch, H P Kiener, R Byrne, B Niederreiter, C W Steiner, E Rath, M Bergmann, J S Smolen, C Scheinecker

Arthritis Rheum

Mar 07, 2013

View on PubMed

HO-1 end products Biliverdin and carbon monoxide ameliorate murine collagen induced arthritis.

M. Bonelli, A. Savitskaya, C.-W. Steiner, E. Rath, M. Bilban, O. Wagner, F.H. Bach, J.S. Smolen, C. Scheinecker

Clin Exp Rheumatol

Jan 01, 2012

View on PubMed

Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells. J Autoimmun.

Clemens Scheinecker, Michael Bonelli, Josef S. Smolen

Journal of Autoimmunity

Nov 07, 2010

View on PubMed

Treg and lupus.

M Bonelli, J S Smolen, C Scheinecker

Annals of the Rheumatic Diseases

Dec 07, 2009

View on PubMed

New Lab Member - Mar Corgos

We are happy to have welcomed Mar Corgos to our team since last December!
Mar recently defended her Bachelor thesis at the IQS Barcelona and completed her internship on Tendon/Ligament scaffold generation at Fachhochschule Technikum Wien.
She is working in our team as a Master Student under the mentoring of Marie Brinkmann on targeting osteoclastogenesis in rheumatoid arthritis: characterizing epigenetic drug mechanisms.

Welcome Mar, we wish you a smooth on-boarding and successful time with us!

Jan 10, 2025

Launch of a new IHI project - AutoPix

AutoPix-project has officially started and we as the Bonelli Lab are proud to be part of it!
This new Innovative Health Initiative (IHI) co-funded by the European Union and the pharma industry aims to revolutionize imaging biomarkers for patients with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis.
Our contribution, together with the team of Costantino Pitzalis at Queen Mary University of London, will link imaging biomarkers to liquid & cellular biomarkers from patients’ biopsies.

Further details of AutoPix are found here: https://lnkd.in/dURfhvdA

Jan 03, 2025

Lilly Innovation Award received by Marie

We are proud to share that our PhD student, Marie Brinkmann, has been awarded the Eli Lilly and Company Award at this year’s Congress of the Austrian Society of Rheumatology – Österreichische Gesellschaft für Rheumatologie & Rehabilitation (ÖGR). 🎉
This competitive award supports outstanding pilot projects in rheumatology with up to 12 months of funding, and it will help advance Marie’s important research in the field.
Congratulations to Marie on this well-deserved recognition!

Dec 13, 2024

Spotlight on rheumatic diseases & research in ORF

Delve into future personalized medical approaches in rheumatology with Daniel Aletaha and Michael Bonelli, featured in an ORF interview.

We express our gratitude to ORF for their support in raising awareness about rheumatic diseases and research.

The full in can be watched here in German: https://tv.orf.at/treffpunkt2142.html (jump to 33:16 for our part).

Dec 06, 2024

Ludwig Boltzmann Institue for Network Medicine

🎉Exciting times for science! The Ludwig Boltzmann Institute for Network Medicine (LBI NetMed) officially launched under the leadership of Jörg Menche.  This innovative research initiative, supported by the Ludwig Boltzmann Gesellschaft aims to tackle complex challenges at the intersection of medicine and network science.
Michael had the pleasure of attending the vibrant welcome party, complete with guided tours of the institute’s cutting-edge facilities and live music that set the tone for a promising future. 
Congratulations to Jörg and the entire team at LBI NetMed! Wishing you groundbreaking discoveries and success in your mission to redefine network medicine. 🚀
Check out more about LBI NetMed here: https://netmed.lbg.ac.at/

Nov 29, 2024

Funded Post-doctoral Researcher position in the field of Autoimmunity

We are looking for a highly motivated, curiosity-driven and independent Postdoctoral Researcher to join our research team to explore molecular mechanisms leading to the development of immune-related non-communicable diseases (IR-NCD), with a focus on rheumatic diseases, in particular Rheumatoid Arthritis (RA).

Further information here: https://innere-med-3.meduniwien.ac.at/en/unsere-abteilungen/rheumatologie/research/group-of-michael-bonelli/jobangebote/phd-student-position-fully-funded-start-march-2024-3/

Nov 26, 2024

Our Team at the Squeeze General Assembly, Bucharest

We were thrilled to reconnect with our partners Costantino Pitzalis and Felice Rivellese from Queen Mary University of London, at the latest SQUEEZE project general assembly in Bucharest! 🤝 One of the focus was on the BioTest trial and refining our strategies to advance precision medicine for RA patients. 🧬 Alongside our experts Peter Mandl MD, PhD, Leonhard Heinz, Lisabeth Emilius, and our scientific project manager François Bonnay, PhD, we renewed our shared commitment to establish groundbreaking biomarkers for treatment success using synovial biopsies. 🔬
A heartfelt thank you to the SQUEEZE and Carol Davila University of Medicine and Pharmacy teams for organizing such a productive and energizing meeting! 🌟

Nov 14, 2024

Our PhD student Mirjam Dellinger started a collaboration in London!

We are thrilled to announce that our talented PhD student Mirjam Dellinger has successfully started a six-months collaboration with the team of Costantino Pitzalis and Felice Rivellese at Queen Mary University of London within the frame of the ambitious Horizon-Europe SQUEEZE project!

Among other things, Mirjam will learn to process and analyze synovial biopsy samples from Rheumatoid Arthritis patients, a key expertise from Queen Mary University of London, and an important task within SQUEEZE that will ultimately advance Precision Medicine for RA patients. Our thanks also go to Costantino and Felice for welcoming Mirjam in their team, and to SQUEEZE and the Marietta Blau-Stipendium (Austria’s Agency for Education and Internationalization) for the financial support of this collaboration.

Sep 25, 2024

Funded Master thesis in the field of autoimmunity (call closed)

📣Our lab is recruiting again, help us spread the word! 📣 We are offering a (paid) Master student position to study with us the role of epigenetic modifications in Arthritis. Check our job ad on the link or the attached pictures below 👇

https://innere-med-3.meduniwien.ac.at/unsere-abteilungen/rheumatologie/wissenschaft-forschung/arbeitsgruppe-michael-bonelli/jobangebote/phd-student-position-fully-funded-start-march-2024/

Universitätsklinik für Innere Medizin III

Aug 28, 2024

Our Team celebrates summer in Vienna!

Our team is embracing the summer in Vienna and proudly accomplished a “Rätselrallye” during our annual summer retreat last week! This activity consisted in a treasure hunt and riddle-solving exercise testing our dedicated researchers on their knowledge of our beloved city. Well-deserved dinner & drinks followed to reward our team. Summery greetings from Vienna!

Medical University of Vienna

Aug 23, 2024

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